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Murugan, V.
- Androgenic Activity of the Total Alkaloid Fraction of Alangium salviifolium (Linn.F)
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Journal of Natural Remedies, Vol 2, No 1 (2002), Pagination: 66-70Abstract
Objective: To perform the androgenic and anti-androgenic activity of the total alkaloid fraction of Alangium salviifolium (Family: Alangiaceae). Materials and methods: The total alkaloid fraction of the methanolic extract of stem bark of Alangium salviifolium was used for the experiment. Immature male albino rats received orally a dose of 10 mg and 20 mg/kg body weight of the fraction for 7 days. The weight of the reproductive organs of the treated rats was measured on the eighth day of the treatment and histometric measurements were carried out. Results: A significant increase in the weight of testis, seminal vesicles, ventral prostate and epididymis was observed in the treated rats. Conclusion: The results suggest the androgenic behaviour of the total alkaloid fraction.Keywords
Alangium salviifolium, Total Alkaloid Fraction, Androgenic ActivityFull Text
- Is Child Rearing Practice Influence the Child Adaptive Behaviour in School?
Abstract Views :139 |
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Authors
G. Maheswari
1,
S. Menu Krishnana
2,
V. Murugan
2,
V. S. Vimal Kumar
2,
Selma Thomas
2,
P. Mythili
2,
R. Mani
2
Affiliations
1 Saveetha University, Chennai, IN
2 Dhanvantri College of Nursing, Namakkal (Dt), IN
1 Saveetha University, Chennai, IN
2 Dhanvantri College of Nursing, Namakkal (Dt), IN
Source
International Journal of Nursing Education and Research, Vol 2, No 3 (2014), Pagination: 237-240Abstract
Child rearing behaviors are directly perceived, interpreted and evaluated by the child while adaptive behaviors are indirectly perceived, interpret and evaluated by others. But these two behaviors are directly influence the personal development of the child.
Objectives: The main objectives of this study are to assess the correlation between the child rearing practices and adaptive behaviour in school going children.
Design: A descriptive research design was used for the study.
Setting: SRK matriculation school at Pachampalayam, Namakkal (Dist).
Sample: School going children, SRK matriculation school at Pachampalayam, Namakkal (Dist).
Sampling Technique: Purposive sampling technique was used.
Sampling criteria: School going children in the age group of 6-8 years and both the sex. Data collection: Rating scale was used to collect the data.
Result: From the findings of the study it can be conclude that the highest percentage of childrens were in the age group of 8 years. Most of them were female.Most of the children where the second child, Educational status of the mother were good, illiterate mothers are very rare and most of them were unemployed.60% of the mothers were authoritative in child rearing practice and similarly 60% of the children having well adaptive behaviour.
Conclusion: The study can be concluded that there is a significant positive correlation between the child rearing practices and child adaptive behaviour.
Keywords
Child Rearing Practices, Adaptive Behaviour, School Going Children, Correlation.
- Synthesis of 2-Imino-3-(5-Aryl-1, 3, 4-Thiadiazol-2-Yl)-5-Arylidene-1, 3-Thiazol-4-One as Potent CNS Depressant and Antimicrobial Agents
Abstract Views :157 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry and Pharmacology, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bengaluru-560078, Karnataka State, IN
1 Department of Pharmaceutical Chemistry and Pharmacology, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bengaluru-560078, Karnataka State, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 3 (2010), Pagination: 698-702Abstract
2-Imino-3-(5-aryl-1, 3, 4-thiadiazolyl)-1,3-thiazol-4-one (E) have been synthesized from Arylaldehyde and Thiosemicarbazide. Condensation of the Iminothiazol-4-one with different substituted aromatic aldehyde and fused sodium acetate in glacial acetic acid to get 2-Imino-5-(4-substituted arylidene)-3-(5-aryl-1, 3, 4-thiadiazol-2-yl)-1,3- thiazol-4-one (F1-7). The structures of the synthesized compounds were conformed on the basis of spectral data. The compounds have been screened for their possible CNS depressant and anti microbial activities. Among the synthesized compounds F1, F2, F4 and F7 showed significant CNS depressant activity and compounds F1, F2, F4 and F6 showed moderate antimicrobial activity.Keywords
2-Imino-5-(4-Substituted Arylidene)-3-(5-Aryl-1, 3, 4-Thiadiazol-2-Yl)-1, 3-Thiazol-4-One, CNS Depressant, Antimicrobial Activity.- Synthesis of Some 1-[Bis-N, N-(2-Chloroethyl) Aminoacetyl]-3, 5-Disubstituted-1, 2-Pyrazolines as Possible Alkylating Anticancer Agents
Abstract Views :159 |
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Authors
Affiliations
1 Dayanandasagar College of Pharmacy, Bangalore, Karnataka, IN
2 JSS College of Pharmacy, Ooty, Tamilnadu, IN
3 JKKMMRS College of Pharmacy, Kumarapalayam, Tamilnadu, IN
1 Dayanandasagar College of Pharmacy, Bangalore, Karnataka, IN
2 JSS College of Pharmacy, Ooty, Tamilnadu, IN
3 JKKMMRS College of Pharmacy, Kumarapalayam, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 496-499Abstract
A series of 1-[Bis-N, N-(2-Chloroethyl) aminoacetyl]-3,5-disubstituted-1,2 pyrazolines have been synthesized by the treatment of 1-[Bis-N, N-(2-hydroxyethyl) aminoacetyl]-3,5-disubstituted-1,2-pyrazolines with Phosphorous oxychloride, the starting compound pyrazoline was synthesized from various aldehydes and acetophenones. The synthesized compounds have been characterized by their analytical, IR, 1H-NMR and mass spectral data. The titled compounds were investigated for their possible anticancer activities by in vitro and in vivo methods. These compounds were found to exhibit a moderate anticancer activity when compared to cyclophosphamide employed as a reference drug for comparison.Keywords
Synthesis, Pyrazoline Derivatives, Anticancer Activity, Dalton’s Lymphoma Ascite (DLA) Cell Line.- Synthesis and Biological Evaluation of Some 2-(N-Substituted Hydrazino)-N-[4-(5-Methyl Benzoxazol-2-Yl)-Phenyl]-Acetamide
Abstract Views :150 |
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Authors
Affiliations
1 Department of Pharamaceutical Chemistry, J.S.S. College of Pharmacy, Rocklands, Ooty, Tamil Nadu, IN
2 Department of Pharmaceutical Chemistry and Pharmacology, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore-560078, Karnataka State, IN
1 Department of Pharamaceutical Chemistry, J.S.S. College of Pharmacy, Rocklands, Ooty, Tamil Nadu, IN
2 Department of Pharmaceutical Chemistry and Pharmacology, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore-560078, Karnataka State, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 457-460Abstract
The reaction of 2-Hydrazino-N-[4-(5-methyl benzoxzol-2-yl)-phenyl]-acetamide (III) with various aldehydes to get 2-(N1-Substituted hydrazino)-N-[4-(5-methyl-benzoxazol-2-yl)-phenyl]-acetamide. The structures of the synthesized compounds were settled on the basis of spectral data. The newly synthesized compounds were tested for their possible antimicrobial and anti-inflammatory activities. After 3 hr, all the tested benzoxazole compounds showed statically significant decrease in the paw volume and all the compounds were tested for their antimicrobial activities none of the compounds showed activity at the concentration of 1000 μg/well.Keywords
Benzoxazole Derivatives, Anti-Inflammatory, Antimicrobial Activity.- Simultaneous Estimation of Paracetamol and Zaltoprofen in Pharmaceutical Dosage Form by HPTLC
Abstract Views :196 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, IN
2 Lotus Labs, Vasanth Nagar, Bengaluru, IN
1 Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, IN
2 Lotus Labs, Vasanth Nagar, Bengaluru, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2075-2078Abstract
Objective: A method for HPTLC was developed and validated for simultaneous estimation of Paracetamol and Zaltoprofen in a pharmaceutical dosage form. Methods: The Chromatographic separation was achieved on TLC aluminum plates precoated with silica gel G60 F254 as the stationary phase. The mobile phase consisted of Hexane: Chloroform: Methanol in the ratio of 3.5:5.5:1v/v/v. Results: The method was found to be linear in the concentration range of 0.8-4μg/spot for PCM and 0.2-1 μg/spot for ZLT and the correlation coefficient were found to be 0.996 for PCM and 0.998 for ZLT. The %RSD value obtained for intraday precision were 0.237 and 0.377 and for inter-day precision were 0.259 and 0.766 respectively, the low % RSD indicates that proposed method is precise as per ICH guidelines. The accuracy of the method was determined and the mean recovery of PCM was 99.73-100.15% and ZLT was 99.57-100.18%. LOD and LOQ values were found to be 0.034 μg/spot and 0.105 μg/spot for PCM, 0.006μg/spot and 0.018 μg/spot for ZLT. Conclusion: The method reported is accurate, precise, specific, robust and linear for the estimation of Paracetamol and Zaltoprofen in Pharmaceutical dosage form.Keywords
Paracetamol, Zaltoprofen, HPTLC, Chromatography, HPTLC.References
- Smita J Pawar et al., HPTLC estimation of Paracetamol, Diclofenac Sodium and Chlorzoxazone in Tablet dosage form. Asian J.Research Chem. 2009;2(3): 306-9.
- Sohan S Chitlange, Ranjana Soni, Sagar B Wankhede and Amol A Kulkarni, Spectrophotometric Methods for Simultaneous Estimation of Dexibuprofen and Paracetamol. Asian J.Research Chem. 2009;2(1): 30-33.
- Godse VP et al., Reverse phase HPLC method for determination of Aceclofenac and Paracetamol in tablet dosage form. Asian J.Research Chem. 2009;2(1): 37-40.
- Makoto MM, Ueda IH, NSAID zaltoprofen possesses novel antinociceptive mechanism through blockage of B2-type bradykinin receptor in nerve endings Neuro. Letters. 2006; 397: 249–253.
- International Conference on Harmonization, Q2 (R1), Harmonized tripartite guidelines, Validation of analytical procedures: text and methodology, Geneva, November 2005.
- Karbhari PA, Joshi SJ, Bhoir SI. RP-LC gradient elution method for simultaneous determination of related substances of Zaltoprofen and Paracetamol and application for drug excipient compatibility study. International Journal of Pharmaceutical Sciences and Research. 2014;6:698-703.
- Archana Ambekar. Validated stability-indicating HPTLC method for simultaneousestimation of Paracetamol and Aceclofenac and their impurities. J Chromatogr SepTech 2016;7:324.
- Deepa Moye Shrestha, Srinivasa Rao T, Sreedhar C, Akkamma HG, Bharadwaja Reddy G, Purushotam Kumar Yadav. Development and validation of analytical method for the simultaneous estimation of Naproxen and Esomeprazole in bulk and pharmaceutical formulation. Bull Pharm Res. 2016;6(1):28-35.
- Dias L, Mallya R, Patani K. Development and validation of new RP-HPLC methodfor estimation of Mephenesin and Ibuprofen. Int J Pharm Sci. Res.2016;7(12):4971-77.
- Manisha S. Phoujdar, Ritesh T. Kucheriya, Shwetal Vassa P.Effect of pH on RP-HPLCmethod development and validation of Ibuprofen in bulk and tablet dosage form. World Journal of Pharmacy and Pharmaceutical Sciences. 2016;5(7):1946-56.
- Abburu Sreedhara Rao, Punna Rao, Mutyala Krishnaji Rao, Anima S Dadhich. Development and validation of RP-HPLC method for assay of Acetylsalicylic acid informulations. European Journal of Biomedical and Pharmaceutical Sciences. 2016;3(5):348-353.Kumaraswamy Gandla, Harika T, Lalitha R. Development and Validation of RP-HPLC Method for Simultaneous Estimation of Aceclofenac and Tramadol in Tablet Dosage Form. Asian J Res Pharm Sci. 2015;5(3):135-138.
- Haritha Gali, Vishwanadham Yerragunta. Development and validation of RP-HPLC method for simultaneous estimation of Naproxen and Esomeprazole in Pharmaceutical dosage form. Journal of Innovations in Pharmaceutical and Biological Sciences. 2016;3(3):39-42.
- Implementation of Quality by Design Approach for Method Development and Validation: A Review
Abstract Views :82 |
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Authors
Affiliations
1 Research Scholar, College Of Pharmaceutical Sciences, Dayananda Sagar University, Bangalore-560078,, IN
2 Associate Professor, College of Pharmaceutical Sciences, Dayanandasagar University, Bengaluru-560078, IN
3 Professor and Dean, College of Pharmaceutical Sciences, Dayanandasagar University, Bengaluru-560078,, IN
1 Research Scholar, College Of Pharmaceutical Sciences, Dayananda Sagar University, Bangalore-560078,, IN
2 Associate Professor, College of Pharmaceutical Sciences, Dayanandasagar University, Bengaluru-560078, IN
3 Professor and Dean, College of Pharmaceutical Sciences, Dayanandasagar University, Bengaluru-560078,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 1 (2022), Pagination: 436-440Abstract
QbD is the heart of recent pharmaceutical development. The implementation of QbD principles delivers a cost efficient methodology for delivering quality medicines for users. Regulatory agencies like USFDA and the European medicines agency (EMA) are placing the greater importance on a part of filing. QbD is efficient advances toward progress so as to commence through pre-defined aim and emphasizes manufacturing product and quality process understanding and method control depending on resonance knowledge and quality hazard supervision. Quality cannot be tested in the products but quality should be built by design, it is an essential part of modern approaches to pharmaceutical quality.under this concept of QbD throughout designing and development of a product. It is important to define the performance profile of the desired product, the quality profile of the target product, and identify critical quality attributes.Keywords
Quality by design, Analytical method validation.References
- Bhusnure OG, Gholve SB, Bawage M, Vinod T. Analytical method development and validation of prednisolone sodium phosphate by QbD approach. IOSR Journal of Pharmacy and Biological Sciences 2015; 10(6): 64-75.
- Hasnain MS, Siddiqui S, Rao S. QbD driven development and validation of a bioanalytical LC-MS method for quantification of Fluoxetine in human plasma. Journal of chromatographic sciences. 2016; 54(5); 736-743.
- Shah AD, Patel CN. Implementation of QbD approach to the RP-HPLC method development and validation of Roflumilast in bulk and tablet dosage form: an application in degradation study. World Journal of Pharmacy and Pharmaceutical Sciences 2014; 3(6); 2281-2307.
- Chaphekar MM, Hamrapurkar PD. Development and validation of RP- HPLC assay method for Vildagliptin using QbD approach and its application to forced degradation studies. International Journal of Pharmaceutical Sciences and Drug Research 2016; 8(3): 157-165.
- Bhusnure OG, Gandge NV, Gholve SB. QbD approach for analytical method development and validation of melatonin by spectroscopic method. Journal of Pharmacy Research 2017; 11(5): 464-471.
- Sahoo CK, Sudhakar M, Sahoo NK, Rao SRM. Validation of Analytical Methods: A Review. Journal of Innovation in Pharmaceutical Sciences 2017; 1(3): 8-13.
- Sandhu PS, Beg S, Singh B. QbD- driven development and validation of a HPLC method for estimation of Tamoxifen citrate with improved performance. Journal of Chromatographic Science 2016; 54(8); 1373-1384.
- Sachin B. Gholve, Rani R. Ajfunde, Omprakash G.Bhusnure and sanjay S. Thonte. Analytical method development and validation by QbD approach. Pelagia Research Library, 2015; 6(8); 18-24.
- ICH Technical requirements for the registration of pharmaceutical human use, Pharmaceutical development Q8 (R2). Harmonised Tripartite Guideline, 2009; 1-28 10. USFDA FDA’s Pharmaceutical current Good Manufacturing Practices for the 21st century A risk based Approach: Final report.2003
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- Raman NVVSS, Mallu UR, Bapatu HR. Analytical quality by design approach to test method development and validation in drug substance manufacturing. Journal of Chemistry. 2015; 1-8.
- Panda SS, Beg S, Venkata RK et. al. Implementation of Quality by Design Approach for developing chromatographic methods with enhanced performance.Journal of Analytical and Pharmaceutical Research 2016; 2(6).
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- ICH Topic Q8 (R2). ICH Harmonised tripartite guideline. In proceedings of the international Conference on Harmonization of Technical requirements for registration of pharmaceuticals for human use (ICH 09), Pharmaceutical Development. 2009
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- Yadav NK, Raghuvanshi A, Sharma G. QbD based development and validation of stability indicating HPLC method for estimating Ketoprofen In bulk drug and proniosomal vesicular system J Chromatogr Sci 2016; 54(3): 377-89.
- Khurana RK, Beg S, Lal D et al., Analytical quality by design approach for development of a validated bioanalytical UPLC method for docetaxel trihydrate. Current Pharmaceutical Analysis 2015; 11(3): 180-192.
- Hasnain MS, Siddiqui S, Rao S et al. QbD- Driven development and validation of a bioanalytical LC-MS method for quantification of fluoxetine in human plasma.Journal of Chromatographic Sciences. 2016; 54(5): 736-743.
- Beg S, Chaudhary V, Sharma G et al. QbD oriented development and validation of a bioanalytical method for nevirapine with enhanced liquid- liquid extraction and chromatographic separation. Biomedical Chromatography 2016; 30(6): 818-828.
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